Mortality Time Trend for Major Viral Pathogens Causing Acute Respiratory Failure in Brazilian Children and Adolescents Before and During the SARS-Cov-2 Pandemic

Background – Little is known about the time trend in mortality rates due to respiratory viruses other than SARS-CoV-2 and seasonal influenza among Brazilian children adolescents. Methods Study outcomes were A, B, syncytial virus, metapneumovirus, rhinovirus, parainfluenza, adenovirus, bocavirus, for age groups <5, 5-9, 10-19 years of age, Brazil, over 2009-2022 period. Secondary data from Ministry Health analyzed by interval regression, bounded between reported deaths estimated upper limit this number, which took into account underestimation deaths, error attributing its causes official records, variation Poisson distribution. Results - For all viruses, varied little under five increased gradually 5-10 11-19-years old. The highest average per million inhabitants period virus (1.04), with lowest values parainfluenza (0.54) B (0.55), intermediate range 0.90 0.95 except SARS-Cov-2. Age 5-9 had similar far largest contributors overall analyzed. Conclusion Schoolchildren Brazil has been rising at least before COVID-19 pandemic, remained elevated during pandemic. In addition influenza, showed a non-ignorable impact on group.